USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: Q9BYX4 USC-OGP 2-DE database:  Q9BYX4 Q9BYX4 General information about the entry View entry in simple text format Entry name IFIH1_HUMAN Primary accession number Q9BYX4 Secondary accession number(s) Q9H3G6 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Interferon-induced helicase C domain-containing protein 1; EC=3.6.4.13; AltName: Full=Clinically amyopathic dermatomyositis autoantigen 140 kDa; Short=CADM-140 autoantigen; AltName: Full=Helicase with 2 CARD domains; Short=Helicard; AltName: Full=Interferon-induced with helicase C domain protein 1; AltName: Full=Melanoma differentiation-associated protein 5; Short=MDA-5; AltName: Full=Murabutide down-regulated protein; AltName: Full=RIG-I-like receptor 2; Short=RLR-2; AltName: Full=RNA helicase-DEAD box protein 116;. Gene name Name=IFIH1 Synonyms=MDA5, RH116 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1105: pI=5.51; Mw=115893 Cross-references UniProtKB/Swiss-Prot Q9BYX4; IFIH1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name IFIH1_HUMAN Primary accession number Q9BYX4 Secondary accession number(s) Q2NKL6 Q6DC96 Q86X56 Q96MX8 Q9H3G6 Sequence was last modified on  March 20, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 152) Name and origin of the protein Description RecName: Full=Interferon-induced helicase C domain-containing protein 1; EC=3.6.4.13; AltName: Full=Clinically amyopathic dermatomyositis autoantigen 140 kDa; Short=CADM-140 autoantigen; AltName: Full=Helicase with 2 CARD domains; Short=Helicard; AltName: Full=Interferon-induced with helicase C domain protein 1; AltName: Full=Melanoma differentiation-associated protein 5; Short=MDA-5; AltName: Full=Murabutide down-regulated protein; AltName: Full=RIG-I-like receptor 2; Short=RLR-2; AltName: Full=RNA helicase-DEAD box protein 116; Gene name Name=IFIH1 Synonyms=MDA5, RH116 Encoded on Name=IFIH1; Synonyms=MDA5, RH116 Keywords 3D-structure; Aicardi-Goutieres syndrome; Alternative splicing; Antiviral defense; ATP-binding; Complete proteome; Cytoplasm; Diabetes mellitus; Disease mutation; Helicase; Host-virus interaction; Hydrolase; Immunity; Innate immunity; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding; Ubl conjugation; Zinc. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF095844; AAG34368.1; -; mRNA EMBL AY017378; AAG54076.1; -; mRNA EMBL BC046208; AAH46208.1; -; mRNA EMBL BC078180; AAH78180.1; ALT_SEQ; mRNA EMBL BC111750; AAI11751.1; -; mRNA EMBL AK056293; BAB71141.1; ALT_INIT; mRNA CCDS CCDS2217.1; -. [Q9BYX4-1]; . RefSeq NP_071451.2; NM_022168.3. [Q9BYX4-1]; . UniGene Hs.163173; -; . PDB 2RQB; NMR; -; A=896-1025 PDB 3B6E; X-ray; 1.60 A; A=277-490 PDB 3GA3; X-ray; 1.45 A; A=893-1017 PDB 4GL2; X-ray; 3.56 A; A/B=306-1017 PDBsum 2RQB; -; . PDBsum 3B6E; -; . PDBsum 3GA3; -; . PDBsum 4GL2; -; . ProteinModelPortal Q9BYX4; -; . SMR Q9BYX4; -; . BioGrid 122082; 15; . DIP DIP-42607N; -; . IntAct Q9BYX4; 20; . MINT MINT-3381993; -; . STRING 9606.ENSP00000263642; -; . iPTMnet Q9BYX4; -; . PhosphoSitePlus Q9BYX4; -; . BioMuta IFIH1; -; . DMDM 134047802; -; . EPD Q9BYX4; -; . MaxQB Q9BYX4; -; . PaxDb Q9BYX4; -; . PeptideAtlas Q9BYX4; -; . PRIDE Q9BYX4; -; . Ensembl ENST00000263642; ENSP00000263642; ENSG00000115267. [Q9BYX4-1]; . Ensembl ENST00000421365; ENSP00000408450; ENSG00000115267. [Q9BYX4-2]; . GeneID 64135; -; . KEGG hsa:64135; -; . UCSC uc002uce.5; human. [Q9BYX4-1]; . CTD 64135; -; . DisGeNET 64135; -; . GeneCards IFIH1; -; . HGNC HGNC:18873; IFIH1; . HPA HPA002656; -; . MalaCards IFIH1; -; . MIM 182250; phenotype; . MIM 606951; gene; . MIM 610155; phenotype; . MIM 615846; phenotype; . neXtProt NX_Q9BYX4; -; . OpenTargets ENSG00000115267; -; . Orphanet 51; Aicardi-Goutieres syndrome; . PharmGKB PA134889215; -; . eggNOG KOG0354; Eukaryota; . eggNOG COG1111; LUCA; . GeneTree ENSGT00510000046789; -; . HOGENOM HOG000230992; -; . HOVERGEN HBG106019; -; . InParanoid Q9BYX4; -; . KO K12647; -; . OMA EIICKCG; -; . OrthoDB EOG091G01PQ; -; . PhylomeDB Q9BYX4; -; . TreeFam TF330258; -; . Reactome R-HSA-168928; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-5689896; Ovarian tumor domain proteases; . Reactome R-HSA-918233; TRAF3-dependent IRF activation pathway; . Reactome R-HSA-933541; TRAF6 mediated IRF7 activation; . Reactome R-HSA-933542; TRAF6 mediated NF-kB activation; . Reactome R-HSA-933543; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; . Reactome R-HSA-936440; Negative regulators of RIG-I/MDA5 signaling; . ChiTaRS IFIH1; human; . EvolutionaryTrace Q9BYX4; -; . GeneWiki MDA5; -; . GenomeRNAi 64135; -; . PRO PR:Q9BYX4; -; . Proteomes UP000005640; Chromosome 2; . Bgee ENSG00000115267; -; . CleanEx HS_IFIH1; -; . Genevisible Q9BYX4; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005634; C:nucleus; IEA:UniProtKB-SubCell; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0003677; F:DNA binding; IEA:InterPro; . GO GO:0003725; F:double-stranded RNA binding; IDA:UniProtKB; . GO GO:0004386; F:helicase activity; IEA:UniProtKB-KW; . GO GO:0043021; F:ribonucleoprotein complex binding; IPI:UniProtKB; . GO GO:0003727; F:single-stranded RNA binding; IDA:UniProtKB; . GO GO:0008270; F:zinc ion binding; IDA:UniProtKB; . GO GO:0039528; P:cytoplasmic pattern recognition receptor signaling pathway in response to virus; TAS:UniProtKB; . GO GO:0009597; P:detection of virus; TAS:BHF-UCL; . GO GO:0045087; P:innate immune response; TAS:UniProtKB; . GO GO:0039530; P:MDA-5 signaling pathway; IDA:UniProtKB; . GO GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome; . GO GO:0032727; P:positive regulation of interferon-alpha production; IMP:UniProtKB; . GO GO:0032728; P:positive regulation of interferon-beta production; IDA:UniProtKB; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0016925; P:protein sumoylation; IDA:UniProtKB; . GO GO:0034344; P:regulation of type III interferon production; TAS:UniProtKB; . GO GO:0009615; P:response to virus; TAS:UniProtKB; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 1.10.533.10; -; 1; . Gene3D 3.40.50.300; -; 2; . InterPro IPR031964; CARD_dom; . InterPro IPR011029; DEATH-like_dom; . InterPro IPR006935; Helicase/UvrB_N; . InterPro IPR014001; Helicase_ATP-bd; . InterPro IPR001650; Helicase_C; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR021673; RIG-I_C-RD; . Pfam PF16739; CARD_2; 2; . Pfam PF00271; Helicase_C; 1; . Pfam PF04851; ResIII; 1; . Pfam PF11648; RIG-I_C-RD; 1; . SMART SM00487; DEXDc; 1; . SMART SM00490; HELICc; 1; . SUPFAM SSF52540; SSF52540; 6; . PROSITE PS51192; HELICASE_ATP_BIND_1; 1; . PROSITE PS51194; HELICASE_CTER; 1; . PROSITE PS51789; RLR_CTR; 1; .

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